High-yield transgenic mammalian expression system for generating virus-like particles
The present invention provides a method utilizing mammalian expression system for generating virus-like particles (VLPs) of mammalian-hosted viruses, particularly SARS-CoV. The method of the present invention involves expression of viral structural proteins in Vero cells and thereby obtaining recomb...
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Main Authors | , , , |
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Format | Patent |
Language | Chinese English |
Published |
16.03.2008
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides a method utilizing mammalian expression system for generating virus-like particles (VLPs) of mammalian-hosted viruses, particularly SARS-CoV. The method of the present invention involves expression of viral structural proteins in Vero cells and thereby obtaining recombinant VLPs in the culture medium. SARS-VLPs generated by the method of the present invention are highly immunogenic and can elicit not only humoral but also cellular immune responses in a mammal. |
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Bibliography: | Application Number: TW20060146898 |