Promoting neochondrogenesis using kinase inhibitors

This invention provides methods for utilizing compounds that inhibit cyclin-dependent kinase and tyrosine kinase enzymes in the promotion of neochondrogenesis and the enhancement, protection and repair of cartilage. In certain embodiments the invention relates to methods of using compounds of formul...

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Bibliographic Details
Main Authors BRAMMER, DAVID WAYNE, KORNISKI, BRIAN CRAIG, BARAGI, VIJAYKUMAR MAHALINGAPPA, COURTNEY, CYNTHIA LEE, LESCH, CHARLES ALFRED
Format Patent
LanguageChinese
English
Published 16.08.2006
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides methods for utilizing compounds that inhibit cyclin-dependent kinase and tyrosine kinase enzymes in the promotion of neochondrogenesis and the enhancement, protection and repair of cartilage. In certain embodiments the invention relates to methods of using compounds of formula I: , and pharmaceutically acceptable salts thereof, to promote neochondrogenesis, wherein, R1, R2, R3, R4, R5, R6, A, B, D, and E have any of the values defined therefor in the specification.
Bibliography:Application Number: TW200594134143