5-substituted-2-phenylamino benzamides as MEK inhibitors

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliterative diseases. The compounds of the present invention and pharmaceutically accepta...

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Main Authors MATSUBARA, YASUAKI, SHIMMA, NOBUO, MIWA, MASANORI, ASO, KOUSUKE, TSUJII, SHINJI, AIDA, SATOSHI, KOHCHI, YASUNORI, KOHCHI, MASAMI, MIZUGUCHI, EISAKU, ISSHIKI, YOSHIAKI, IIKURA, HITOSHI, MURATA, TAKESHI
Format Patent
LanguageChinese
English
Published 16.05.2006
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Summary:An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliterative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are same as defined in the present patent application].
Bibliography:Application Number: TW200594125122