GPR35 and modulators thereof for the treatment of metabolic-related disorders

The present invention relates to a method for identifying a metabolic stabilizing compound, comprising: (a) contacting a candidate compound with GPR35, and (b) determining whether GPR35 functionality is increased, wherein an increase in GPR35 functionality is indicative of the candidate compound bei...

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Bibliographic Details
Main Authors CHU, ZHI-LIANG, GAIDAROV, IBRAGIM, LEONARD, JAMES N, BOATMAN, P. DOUGLAS, QIU, JUN, UNETT, DAVID J, SKINNER, PHILIP J, GATLIN, JOEL E
Format Patent
LanguageChinese
English
Published 16.04.2006
Subjects
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:The present invention relates to a method for identifying a metabolic stabilizing compound, comprising: (a) contacting a candidate compound with GPR35, and (b) determining whether GPR35 functionality is increased, wherein an increase in GPR35 functionality is indicative of the candidate compound being a metabolic stabilizing compound. The invention further relates to use of a GPR35 modulator for the manufacture of a medicament for use as a metabolic stabilizing agent. In addition, the invention relates to a method for increasing GPR35 function in vitro, comprising contacting GPR35 with an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is O or S; and R1, R2, R3, R4, and R5 are each independently selected from the group consisting of H, C1-4 alkoxy, C1-4 alkyl, halogen, hydroxyl, and nitro; wherein said C1-4 alkoxy is optionally substituted with carbo-C1-4-alkoxy or carboxy.
Bibliography:Application Number: TW200594116911