Method of preparing cyclopentene nitrile derivatives
The present invention is aimed to provide a method of preparing cyclopentene nitrile derivatives, especially optically resolvable cyclopentene nitrile derivatives, by subjecting a nitrile derivative and an , -unsaturated ketone to conjugate addition reaction. The method has the advantages such as go...
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Main Authors | , , , |
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Format | Patent |
Language | Chinese English |
Published |
01.02.2006
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention is aimed to provide a method of preparing cyclopentene nitrile derivatives, especially optically resolvable cyclopentene nitrile derivatives, by subjecting a nitrile derivative and an , -unsaturated ketone to conjugate addition reaction. The method has the advantages such as good yield, fewer steps, and no need of using expensive reagents or compounds. More specifically, the present invention is related to a novel method of preparing cyclopentene nitrile derivatives in good yield, comprising subjecting an 4-alkoxy-3-butenonitrile derivative (for example, 4-methoxy-3-butenonitrile) which may optionally have an alkyl or ally group on the -position and an , -unsaturated ketone to conjugate addition reaction, then treating the resulting product with acetic anhydride or chlorocarbonate to form an enol ester, and finally treating the enol ester with a strong acid to form a 5-membered ring, thereby forming the cyclopentene nitrile derivative. |
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Bibliography: | Application Number: TW20050106896 |