Peptide deformylase inhibitors

• Main Authors: AUBART, KELLY M, LEE, JINHWA, BENOWITZ, ANDREW B, CHRISTENSEN, IV SIEGFRIED B, KARPINSKI, JOSEPH M, DOMINGOS J SILVA
• Format: Patent
• Language: Chinese; English
• Published: 01.03.2004
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Novel PDF inhibitors and novel methods for their use are provided. 1. A compound according to formula (1): In one aspect of the present invention, there is provided a compound of formula(1): wherein: R is selected from the group consisting of: C2-6 alkyl (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl); C2-6 alkenyl (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl); C2-6 alkynyl (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl); (CH2)n- C3-6 carbocycle (optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl); and (CH2)n-R4, wherein R4 is selected from the group consisting of phenyl, furan, benzofuran, thiophene, benzothiophene, tetrahydrofuran, tetrahydropyran, dioxane, 1, 4-benzodioxane or benzo[1,3]dioxole; R4 is optionally substituted by one or more substituent selected from Cl, Br, I, C1-3 alkyl (optionally substituted by one to three F) and C1-2 alkoxy (optionally substituted by one to three F)}; R1 and R2 are independently selected from the g