Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri

• Main Authors: BRIAN SCOTT BRONK, KAZUO ANDO, MARTHA LOU MINICH, SUBAS MAN SAKYA, K., KAWAMURA, TOMOKI KATO, KRISTIN MARIE LUNDY, JIN LI, HENGMIAO CHENG
• Format: Patent
• Language: Turkish
• Published: 21.01.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Bu bulus, A ve R1'den her birinin istege göre ikame edilen 5 ila 6 üyeli bir heteroaril oldugu, heteroarilin istege göre bir karboksilik halkasi veya 5 ila 6-heteroarile baglandigi; R2'nin istege göre halo, amino veya bir alkil amino ile ikame edilen (C1-C4)alkil oldugu; R3 ve R4'ten her birinin hidrojen, halo, istege göre halo ile ikame edilen (C1-C4) alkil ve benzeri oldugu; ve X1 ila X4'ten her birinin hidrojen, halo, hidroksi, istege göre halo ile ikame edilen (C1-C4)alkil ve benzeri oldugu asagidaki formüle ait bir bilesik: (Formül(I)); veya bunun farmasötik açidan kabul gören bir tuzu ile ilgilidir. Bu bilesikler, COX-2 önleyici aktiviteye sahiptir ve bu nedenle de iltihaplasmanin veya COX-2 ile ilgili diger hastaliklarin tedavisinde veya önlenmesinde faydalidir. This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R is (C1-C4)alkyl optionally substituted with halo, amino or an alkyl amino; R and R are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X to X are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.