PROCEDE POUR ALKYLER DES SULFONAMIDES A ENCOMBREMENT STERIQUE

• Main Author: JOEL MICHAEL HAWKINS
• Format: Patent
• Language: French
• Published: 10.11.2005
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR RELEVANT APPARATUS; TRANSPORTING

-L'INVENTION CONCERNE UN PROCEDE POUR ALKYLER DES SULFONAMIDES A ENCOMBREMENT STERIQUE PAR ADDITION DE MICHAEL A DES PROPIOLATES. ELLE CONCERNE EGALEMENT LES INTERMEDIAIRES NOUVEAUX PREPARES DANS CE PROCEDE. APPLICATION : TRANSFORMATION DES PRODUITS DE LA REACTION PRECITEE EN INHIBITEURS DES METALLOPROTEINASES DE MATRICE, UTILES COMME MEDICAMENTS DANS LE TRAITEMENT DE DIVERSES MALADIES. The present invention relates to a process for the preparation of compounds of formula (b), in which a compound of formula V is reacted with a compound of formula VI. The resulting compound of formula IV is reduced to a compound of formula III which is hydrolysed to a compound of formula (b). Alternatively, a compound of formula IV is hydrolysed to a compound of formula (a) which reduced to a compound of formula (b). Compounds of formula IV are novel. In the formulae the variables are as defined in the claims.