THIENYL ET FURANYL OXAZOLIDINEDIONES PYRIDO-CONDENSES

• Main Authors: WALTER GUARNIERI, BERND RIEDL, STEPHAN BARTEL, ANDREAS STOLLE, MARTIN RUPPELT, HEIN PETER KROLL, DIETER HABICH, RAINER ENDERMANN
• Format: Patent
• Language: French
• Published: 15.03.2005
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

LA PRESENTE INVENTION CONCERNE DE NOUVELLES THIENYL ET FURANYL- OXAZOLIDINEDIONES PYRIDO-CONDENSES, DES PROCEDES POUR LES PREPARER, ET LEUR UTILISATION EN TANT QUE MEDICAMENTS, EN PARTICULIER EN TANT QUE MEDICAMENTS ANTIBACTERIENS. N-(Pyrido-thienyl or pyrido-furanyl)-oxazolidinone derivatives (I) as pure stereoisomers or stereoisomer mixtures and their salts are new: A = O; S; or SO2; D, E, G, L = at least 1 N atom or -CR ; R = N3; OH; OR ; -OSO2R ; or -NR R ; R = H; CN; COOH; alkyl, acyl or alkoxy with up to 7C; halo; -NR R ; -CO-NR R ; -NH-CO-R ; or S(O)aR ; R -R = H; Ph; or 1-6C alkyl; a = 0-2; R = Ph or 1-4C alkyl; R = acyl with up to 8C or a OH protecting group; R = 1-4C alkyl; or Ph optionally substituted by 1-4C alkyl; R , R = H; 3-6C cycloalkyl; Ph; 1-8C alkyl; 1-8C alkoxy; or a NH2 protecting group; or one of R and R can be -COR , -CSR ', P(O)(OR )(OR ) or -SO2-R ; R , R ' = H; 3-6C cycloalkyl; CF3; 1-8C alkoxy; Ph; Ph-CH2O; 1-8C alkyl optionally substituted by halo, CN or CF3; thioalkyl or acyl with up to 6C; or -NR R ; R , R = H or 1-4C alkyl; R = 1-4C alkyl or Ph; R , R = H; Ph; 1-6C alkyl; or 5-membered heteroaryl containing 1-3 S, N and/or O atoms.