NOUVELLES PYRIDAZINAMINES ET PROCEDE POUR LEUR PREPARATION

• Main Authors: CYRIEL ALPHONS MARIA VAN DER EYCKEN, MARCEL GEREBERNUS MARIA LUYCKX, RAYMOND ANTOINE STOKBROEKX
• Format: Patent
• Language: French
• Published: 05.03.1991
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

L'INVENTION CONCERNE DES PIPERIDINYL-, PYRROLIDINYL-, AZEPINYL- ET PIPERAZINYLE-PYRIDAZINES DE FORMULE (I) DANS LAQUELLE UN OU DEUX ATOMES DE CARBONE DU FRAGMENT PEUVENT ETRE SUBSTITUES OU DEUX ATOMES DE CARBONE DES GROUPES CH2 DUDIT FRAGMENT PEUVENT ETRE PONTES; X, R1, R2, R3, ALK, R4 ET R5 SONT DEFINIS; HET REPRESENTE ET LEURS SELS D'ADDITION D'ACIDES ET LEURS FORMES ISOMERES STEREOCHIMIQUES, UN PROCEDE POUR PREPARER CES COMPOSES EST EGALEMENT DECRIT. Piperidinyl, pyrrolidinyl, azepinyl and piperazinyl pyridazines of formula wherein X represents CH or N; R represents hydrogen, C1-4alkyl, halo, hydroxy, trifluoromethyl, cyano, C1-4alkyloxy, C1-4alkylthio, C1-4alkylsulfinyl, C1-4alkylsulfonyl, C1-4alkyloxycarbonyl, C1-4alkylcarbonyl or aryl; R and R represent hydrogen or C1-4alkyl; Alk represents C1-4alkanediyl; R and R represent hydrogen, C1-4alkyl or halo; and Het represents the addition salts and stereochemically isomeric forms thereof, said compounds having antipicornaviral activity. Pharmaceutical compositions containing these compounds as active ingredient, and methods of preparing said compounds and pharmaceutical compositions.