COMPOSITIONS POLYMERES A LIBERATION CONTROLEE COMPRENANT DES COMPOSES FAVORISANT LA CROISSANCE OSSEUSE

• Main Authors: PARALKAR, Vishwas, Madhav, JEFFERS, Scott, Alexander, ZHOU, Mingxing, DUMONT, Francis, DUNN, Richard, Lee, KORSMEYER, Richard, Wilker, LI, Mei
• Format: Patent
• Language: French
• Published: 01.06.2006
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

LA PRESENTE INVENTION CONCERNE UN SYSTEME PERFECTIONNE POUR LA LIBERATION CONTROLEE D'UN COMPOSE FAVORISANT LA CROISSANCE OSSEUSE; ET UNE COMPOSITION FLUIDE POUR SA FORMATION. LA COMPOSITION FLUIDE EST CONSTITUEE D'UN COMPOSE FAVORISANT LA CROISSANCE OSSEUSE; D'UN POLYMERE THERMOPLASTIQUE ET D'UN SOLVANT ORGANIQUE. LA COMPOSITION FLUIDE EST CAPABLE DE FORMER UNE MATRICE POLYMERE SOLIDE MICROPOREUSE BIODEGRADABLE ET/OU BIOERODABLE. LA MATRICE EST UTILE COMME IMPLANT CHEZ DES PATIENTS (HOMME ET ANIMAUX) POUR DELIVRER UN COMPOSE FAVORISANT LA CROISSANCE OSSEUSE A CERTAINS TISSUS. The present invention is directed to an improved system for controlled release of a bone growth promoting compound and to a flowable composition for its formation. The flowable composition is composed of a bone growth promoting compound, a thermoplastic polymer and an organic solvent. The flowable composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of a bone growth promoting compound to certain tissues.