DERIVES DE BENZIMIDAZOLE NOUVEAUX, ET COMPOSITIONS LES CONTENANT

• Main Authors: MARK ANTHONY DOMBROSKI, MICHAEL ANTHONY LETAVIC, KIM FRANCIS MCCLURE
• Format: Patent
• Language: French
• Published: 23.12.2005
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

L'INVENTION CONCERNE DES COMPOSES DE FORMULE I : DANS LAQUELLE Het REPRESENTE UN HETEROCYCLE PENTAGONAL FACULTATIVEMENT SUBSTITUE ET R1, R2 ET R3 REPRESENTENT L'HYDROGENE OU UN RADICAL ORGANIQUE, ET S EST UN NOMBRE ENTIER DE 0 A 5. ELLE CONCERNE EGALEMENT DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS, COMME INHIBITEURS DE MAP-KINASES, DE PREFERENCE DE LA KINASE P38, DANS LE TRAITEMENT DE DIVERSES MALADIES. The present invention relates to novel triazolo-pyridines of the formula I wherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of said heteroatoms atoms must be nitrogen; R2 is selected from the group consisting of hydrogen, (C1-C6)alkyl or other suitable substituents; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl or other suitable substituents; s is an integer from 0-5; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.