SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF

The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treat...

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Main Authors PAN WEIDONG, MACCOSS MALCOLM, HICKLIN DANNY J, GUZI TIMOTHY J, MA YAO, NOMEIR AMIN, VOSS MATTHEW ERNST, KULKARNI BHEEMASHANKAR A, WANG YAOLIN, TIAN YUAN, GIBEAU CRAIG R, BOGEN STEPHANE L, RINDGEN DIANE, DOLL RONALD J, LIU YUAN, SCAPIN GIOVANNA, KIROVA-SNOVER MARGARITA, NAIR LATHA G, LAHUE BRIAN ROBERT, SHIPPS GERALD W. JR, SHIZUKA MANAMI, SEIDEL-DUGAN CYNTHIA
Format Patent
LanguageEnglish
Published 19.09.2013
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
Bibliography:Application Number: TN20120000129