AMIDE SUBSTITUTED INDAZOLES AS POLY (ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS

The present invention relates to compounds of formula (1) and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic condition...

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Bibliographic Details
Main Authors SCHULTZ-FADEMRECHT,CARSTEN, ONTORIA ONTORIA,JESUS,MARIA, SCARPELLI,RITA, JONES,PHILIP
Format Patent
LanguageEnglish
French
Published 31.12.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds of formula (1) and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases, other than cardiovascular diseases diabetes, neurodegenerat ive diseases retroviral infection, retinal damage or skin senescence and UV- induced skin damage, and as chemo- and/or radiosensitizers for cancer treatment.
Bibliography:Application Number: TN20090000286