Inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine or salts formed with cyclodextrin derivatives preparation thereof and pharmaceutical compositions containing the same

Clathrates (I) of N-ethoxycarbonyl-3- morpholino-sydnonimine (II) or its salts with cyclodextrin derivs. (III) are new. N.B., cpds. (III) include unsubstd. beta- and gamma-cyclodextrins. (II) is an anti-angina and anti-ischaemic agent (molsidomin) useful for prevention and treatment of angina pector...

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Main Authors MARMAROSI KATALIN, GAAL JOZSEF, HERMECZ ISTVAN, VIKMON MARIA, HOVARTH AGNES, HOVARTH GABOR, SZEJTLI JOZSEF, MUNK-ACSI IREN
Format Patent
LanguageEnglish
Published 24.11.1999
Edition6
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:Clathrates (I) of N-ethoxycarbonyl-3- morpholino-sydnonimine (II) or its salts with cyclodextrin derivs. (III) are new. N.B., cpds. (III) include unsubstd. beta- and gamma-cyclodextrins. (II) is an anti-angina and anti-ischaemic agent (molsidomin) useful for prevention and treatment of angina pectoris. It also has antiarrhythmic, fibrinolytic, platelet aggregation inhibitory and hypotensive activity. Pref. (III) are selected from beta-cyclodextrin (BCD), gamma-cyclodextrin, heptakis-2,6,O-dimethyl -beta-cyclodextrin and hydroxypropyl- beta-cyclodextrin.
Bibliography:Application Number: TJ19940000007