COMPUESTOS HETEROARIL- Y FENILSULFAMOILO SUSTITUIDOS REF. PC26197A

• Main Author: HAMANAKA ERNEST SEIICHI
• Format: Patent
• Language: Spanish
• Published: 09.05.2006
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE REFIERE A COMPUESTOS HETEROARIL Y FENILSULFAMOILO SUSTITUIDOS, A COMPOSICIONES FARMACEUTICAS QUE CONTIENE TALES COMPUESTOS Y AL USO DE TALES COMPUETSOS COMO AGONISTAS EL RECEPTOR ACTIVADOR DEL PROLIFERADOR DE PEROXISOMA (PPAR). LOS ACTIVADORES PPPAR ALFA, COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS Y EL USO DE TALES COMPUESTOS SON UTILES PARA ELEVAR CIERTOS NIVELES DE LIQUIDOS EN PLASMA, INCLUYENDO COLESTERIL-LIPOPROTEINA DE ALTE DENSIDAD Y PARA REDUCIR CIERTOS NIVELES DE LIPIDOS DISTINTOS EN PLASMA TALES COMO COLESTEROL-LDL Y TRIGLICERIDOS Y POR CONSIGUIENTE PARA TRATAR ENFERMEDADES QUE EMPEORAN CON BAJOS NIVELES DE COLESTEROL HDL Y/O ALTOS NIVELES DE COLESTEROL-LDL Y TRIGLICERIDOS TALES COMO ATEROESCLEROSIS Y ENFERMEDADES CARDIOVASCULARES EN MAMIFEROS, INCLUYENDO SERES HUMANOS. LOS COMPUESTOS TAMBIEN SON UTILES PARA EL TRATAMIENTO DEL BALANCE ENERGETICO (NEB) Y ENFERMEDADES ASOCIADAS EN RUMIANTES The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans. The compounds are also useful for the treatment of negative energy balance (NEB) and associated diseases in ruminants.