METHOD OF PRODUCING 6-HYDRAZINO-PYRIDO-(2,1-B)-QUINOZALIN-11-ON DERIVATIVES OR SALTS THEREOF

• Main Authors: JOZHEF KEKESHI,HU, TIBOR BRAJNING,HU, AGNESH KHORVAT,HU, LELLE VASHVARI,HU, ISHTVAN KHERMETS,HU, DERD SAS,HU, ZOLTAN MESAROSH,HU
• Format: Patent
• Language: English; Russian
• Published: 15.11.1985
• Edition: 4
• Subjects: CHEMISTRY; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of the general formula (wherein R, R and R , which may be the same or different, each represents a hydrogen or halogen atom or a nitro, carboxy, cyano, C1-4 alkoxy, C1-4 alkyl, amino, or hydroxy group or an alkoxycarbonyl group in which the alkoxy contains 1 to 4 carbon atoms; or R and R together represent a methylenedioxy group, and R represents a hydrogen atom; R represents a hydrogen atom or a C1-4 alkyl group; R represents a hydrogen atom or a C1-4 alkyl group, a naphthyl or pyridyl group or a phenyl group substituted by 1 to 3 substituents, which may be the same or different, selected from halogen, C1-4 alkyl, C1-4 alkoxy, phenoxy, hydroxy, nitro, amino, cyano, carboxy, alkoxycarbonyl in which the alkoxy moiety contains 1 to 4 carbon atoms, alkanoyl in which the alkyl moiety contains 1 to 4 carbon atoms, methylenedioxy, trifluoromethyl, phenyl and mono- or di-alkylamino in which the alkyl moiety contains 1 to 4 carbon atoms; and each dotted line represents an optional further bond and the salts, optical and geometrical isomers and tautomers thereof are intermediates in the preparation of Rutaecarpine and the analogues thereof. The compounds of formula I may be prepared by reaction of a pyrido[2,1-b]quinazolin-11-one with a diazonium salt or with hydrazine or a derivative thereof.