METHOD OF PRODUCING DERIVATIVES OF OXADIAZOLYDINE

A method for the continuous semi-continuous or batchwise production of oxadiazolidine derivatives having the general formula (I), wherein R and R represent an aromatic or heteroaromatic group or a straight- chained, branched or cyclic, saturated or unsaturated C1-6 aliphatic hydrocarbyl group wherei...

Full description

Saved in:
Bibliographic Details
Main Authors YANOSH CHASAR,HU, GEZA TOT,HU, LAJOSH NAD,HU, JOZHEF PETRO,HU, EVA SHOMFAI,HU
Format Patent
LanguageEnglish
Russian
Published 23.09.1985
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:A method for the continuous semi-continuous or batchwise production of oxadiazolidine derivatives having the general formula (I), wherein R and R represent an aromatic or heteroaromatic group or a straight- chained, branched or cyclic, saturated or unsaturated C1-6 aliphatic hydrocarbyl group wherein a hydroxylamine derivative R'NHOH is first reacted with an isocyanate R NCO in a water-miscible solvent at a pH of between 4 and 7.5 to form a free urea derivative HONR CONHR which is then reacted with an alkyl chloroformate to produce a substituted urea of the formula in the presence of an aqueous solution of a base. The alkyl chloroformate is introduced either simultaneously or prior to the base such that the pH of the reaction mixture does not exceed 8. Finally the substituted urea is subjected to ring closure by adjusting the pH of the mixture between 9 and 10.5. The intermediates need not be isolated.
Bibliography:Application Number: SU19823381946