Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids

• Main Authors: WARMUS JOSEPH SCOTT, TECLE HAILE, BARRETT STEPHEN DOUGLAS, BIWERSI CATHLIN, KAUFMAN MICHAEL D, CHEN MICHAEL HUAI GU
• Format: Patent
• Language: English; Slovak
• Published: 03.11.2015
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Also described is oxygenated esters of 4-iodophenylamino acid of formula (III), wherein R1 is hydrogen or halogen and R5 is fluoro or chloro, or a pharmaceutically acceptable salt thereof and its use in the treatment of a proliferative disease selected from the group consisting of cancer, restenosis...