Method for ethinylation of methyl iso-amyl ketone

Described is a method for the preparation of 2,5,8,11-tetramethyl-6-dodecyne-5,8-diol and/or 3,6-dimethyl-1- heptine-3-ol from methyl isoamyl ketone and acetylenic hydrocarbon. Reaction is performed in the presence of potassium alcoholate suspension in the environment of aromatic hydrocarbon at a te...

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Main Authors BENO LUBOS, KAVALA MIROSLAV, CHROMA VIOLA, BORISEK IGOR, KOMORA LADISLAV, JANCICH JOZEF, GROLMUS PETER, HOMOLOVA IVANA, MATISOVA MARTA, HOJC JAN
Format Patent
LanguageEnglish
Slovak
Published 07.12.2009
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Described is a method for the preparation of 2,5,8,11-tetramethyl-6-dodecyne-5,8-diol and/or 3,6-dimethyl-1- heptine-3-ol from methyl isoamyl ketone and acetylenic hydrocarbon. Reaction is performed in the presence of potassium alcoholate suspension in the environment of aromatic hydrocarbon at a temperature of 0 to 60 °C and pressure of 70 to 130 kPa, whereby the molar ratio of potassium alcoholate to ketone or ketone and acetylenic hydrocarbon mixture is lower than 0.822. After ending reaction the mixture being hydrolyzed, neutralized and fractionated at a reduced pressure, whereby both products being isolated. Je opísaný spôsob výroby 2,5,8,11-tetrametyl-6-dodecín-5,8- diolu a/alebo 3,6-dimetyl-1-heptin-3-olu z metylizoamylketónu a acetylénického uhľovodíka. Reakcia sa uskutočňuje v prítomnosti suspenzie alkoholátu draselného v prostredí aromatického uhľovodíka, pri teplote 0 až 60 °C a tlaku 70 až 130 kPa, pričom mólový pomer alkoholátu draselného ku ketónu alebo zmesi ketónu a acetylenického uhľovodíka je menší ako 0,822. Po ukončení reakcie sa zmes hydrolyzuje, neutralizuje a destiluje pri zníženom tlaku, pričom sa izolujú oba produkty.
Bibliography:Application Number: SK20050000108