Method for the production of (S)-N-methyl-3-(1-naphthyloxy)-3-(2- thienyl)propylamine hydrochloride (duloxetine)

(S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride of the formula (I) is obtained in such a manner that a base of (S)-N-methyl-3-(1-naphtyloxy)-3-(2- thienyl)propylamine is brought into reaction with the compound of the general formula III or IV, in which R1, R2, R3 can be H, a br...

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Bibliographic Details
Main Authors KLVANA ROBERT, RIDVAN LUDEK, RADL STANISLAV
Format Patent
LanguageEnglish
Slovak
Published 07.09.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:(S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride of the formula (I) is obtained in such a manner that a base of (S)-N-methyl-3-(1-naphtyloxy)-3-(2- thienyl)propylamine is brought into reaction with the compound of the general formula III or IV, in which R1, R2, R3 can be H, a branched or unbranched alkyl group containing from 1 to 5 carbon atoms or the groups of (CH2)nCOOH, in which n denotes 0 to 5 to form the corresponding hydrochloride. (S)-N-Metyl-3-(1-naftyloxy)-3-(2-tienyl)propylamín hydrochlorid vzorca (I) sa získa tak, že báza (S)-N-metyl-3-(1- naftyloxy)-3-(2-tienyl)propylamínu sa nechá reagovať s látkou všeobecného vzorca (III) alebo (IV), kde R1, R2, R3 môžu byť H, C1-C5 alkylové skupiny, tak nerozvetvené, ako aj rozvetvené, alebo skupiny (CH2)nCOOH, kde n znamená 0 až 5, za vzniku príslušného hydrochloridu.
Bibliography:Application Number: SK20050005078