Method and reagents for the quantification of solid-phase reactions using fluorine NMR

Method of quantitating solid phase reactions comprises:(a) reacting solid phase reaction component or fluorine containing solid phase component with reactant or fluorine containing reactant to form fluorine containing solid phase reaction product; (b) obtaining 19 F NMR spectrum of reaction product;...

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Bibliographic Details
Main Authors ORTON EDWARD, AIREY JOHN E, KROLIKOWSKI PAUL H, NAGULAPALLI VASANT K
Format Patent
LanguageEnglish
Slovak
Published 05.12.2008
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
SURGERY
TESTING
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Summary:Method of quantitating solid phase reactions comprises:(a) reacting solid phase reaction component or fluorine containing solid phase component with reactant or fluorine containing reactant to form fluorine containing solid phase reaction product; (b) obtaining 19 F NMR spectrum of reaction product; and (c) comparing integral corresponding to fluorine containing reaction product 19 F resonance to integral corresponding to standard 19 F resonance. Je opísaný spôsob kvantifikácie reakcie v tuhej fáze, ktorý spočíva v (a) reakcii reakčnej zložky vtuhej fáze medzi reakčnou zložkou v tuhej fáze obsahujúcej fluór a reaktantom alebo reaktantom obsahujúcim fluór pri tvorbe reakčného produktu v tuhej fáze obsahujúceho fluór; (b) v odoberaní vzorky tohto reakčného produktu v tuhej fáze vo vopred stanovenom časovom intervale a získanie 19F NMR spektra tejto reakčnej vzorky a (c) v porovnaní v uvedenom 19F NMR spektre 19F rezonančného signálu zodpovedajúceho reakčnému produktu v tuhej fáze obsahujúceho fluór s 19F rezonančným signálom vnútornéhoštandardu. Vynález umožňuje sledovať priebeh reakcie v tuhej fáze.
Bibliography:Application Number: SK20000000952