Pharmaceutical multiple unit formulation and process for preparing the same
Pharmaceutical multiple unit formulations comprising pellets which are delayed to an identical or different extent consisting of a starter material coated with tramadol or its physiologically tolerable salts, which is coated with one or more membrane layers for controlled release consisting of a sub...
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Main Authors | , , , |
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Format | Patent |
Language | English Slovak |
Published |
05.10.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Pharmaceutical multiple unit formulations comprising pellets which are delayed to an identical or different extent consisting of a starter material coated with tramadol or its physiologically tolerable salts, which is coated with one or more membrane layers for controlled release consisting of a substance from the group of ethylcelluloses having various degrees of ethylation and various chain lengths and/or from the group of shellacs without addition of a softening agent. The formulations are preferably in the form of capsules or tablets. A process for the preparation of said formulation is also disclosed.
Farmaceutické formulácie obsahujú pelety s rovnakým alebo rozdielnym profilom riadeného uvoľňovaniaúčinnej látky, ktoré sú tvorené jadrom potiahnutým najprv tramadolom alebo jeho fyziologicky prijateľnými soľami, a potom jednou alebo niekoľkými vrstvami membrány riadiacej uvoľňovanie účinnej látkya vytvorenej etylcelulózami s rôznym etylačným stupňom a rôznou dĺžkou reťazca a/alebo šelakmi bez prídavku zmäkčovadla. Formulácie majú výhodne formu kapsuly alebo tablety. Opísaný je takisto spôsobvýroby predmetných farmaceutických formulácií. |
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Bibliography: | Application Number: SK19990000098 |