Pharmaceutical multiple unit formulation and process for preparing the same

Pharmaceutical multiple unit formulations comprising pellets which are delayed to an identical or different extent consisting of a starter material coated with tramadol or its physiologically tolerable salts, which is coated with one or more membrane layers for controlled release consisting of a sub...

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Bibliographic Details
Main Authors KUHN DIETER, RABER MARC, SCHMID WOLFGANG, MOMBERGER HELMUT
Format Patent
LanguageEnglish
Slovak
Published 05.10.2006
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Pharmaceutical multiple unit formulations comprising pellets which are delayed to an identical or different extent consisting of a starter material coated with tramadol or its physiologically tolerable salts, which is coated with one or more membrane layers for controlled release consisting of a substance from the group of ethylcelluloses having various degrees of ethylation and various chain lengths and/or from the group of shellacs without addition of a softening agent. The formulations are preferably in the form of capsules or tablets. A process for the preparation of said formulation is also disclosed. Farmaceutické formulácie obsahujú pelety s rovnakým alebo rozdielnym profilom riadeného uvoľňovaniaúčinnej látky, ktoré sú tvorené jadrom potiahnutým najprv tramadolom alebo jeho fyziologicky prijateľnými soľami, a potom jednou alebo niekoľkými vrstvami membrány riadiacej uvoľňovanie účinnej látkya vytvorenej etylcelulózami s rôznym etylačným stupňom a rôznou dĺžkou reťazca a/alebo šelakmi bez prídavku zmäkčovadla. Formulácie majú výhodne formu kapsuly alebo tablety. Opísaný je takisto spôsobvýroby predmetných farmaceutických formulácií.
Bibliography:Application Number: SK19990000098