PROCESS FOR PREPARING 2-CARBOXY-3-[2-(DIMETHYLAMINO)-ETHYL]-N- -METHYL-1H-INDOLE-5-METHANESULFONAMIDE AND LOWER ALKYL ESTERS THEREOF

Prodn. of 3-(2-(dimethylamino) ethyl) -N-methyl -IH-indol-5-methane sulphonamide (I) comprises decarboxylation of 2-carboxy-3-(2-dimethyl amino) ethyl)-N-methyl -IH-indol-5-methane sulphonamide (II) in the presence of a solvent and a catalyst under inert atmos. at 190-250 deg.C. Disclosed is a proce...

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Bibliographic Details
Main Authors BARJOAN PERE DALMASES, GES JOSE MARIA CALDERO, ROVIRA ANA BOSCH, OLONDRIZ FRANCISCO MARQUILLAS
Format Patent
LanguageEnglish
Slovak
Published 10.04.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Prodn. of 3-(2-(dimethylamino) ethyl) -N-methyl -IH-indol-5-methane sulphonamide (I) comprises decarboxylation of 2-carboxy-3-(2-dimethyl amino) ethyl)-N-methyl -IH-indol-5-methane sulphonamide (II) in the presence of a solvent and a catalyst under inert atmos. at 190-250 deg.C. Disclosed is a process for preparing 2-carboxy-3-[2- -(dimethylamino)-ethyl]-N-methyl-1H-indole-5-methanesulfonamide and its lower alkyl esters of the general formula (I) wherein R is H or a C1-6-alkyl group, which process can be characterised in that the compound of the general formula (III), wherein Alk denotes a C1-6-alkyl group and X is a leaving group, reacts with dimethylamine in an organic solvent. Thus produced dimethylaminoester of the general formula (I), wherein R is a C1-6-alkyl group, is optionally saponificated to obtain the compound of the general formula (I), wherein R is H.
Bibliography:Application Number: SK19930000088