SUBSTITUTED PYRIMIDINES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS THEM CONTAINING AND THEIR USE

Disclosed are substituted pyrimidines of the general formula (I) wherein R1, R2, R3 and R4 are independently H, alkyl containing 1 to 6 carbon atoms, or perfluoroalkyl containing 1 to 6 carbon atoms; R5 is H or when n is 1 R5 taken together with R3 comprises a double bond, n is 0 to 1, p is 0 to 2,...

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Bibliographic Details
Main Authors NIKAIDO MADELENE, ELLINGBOE JOHN W, BAGLI JEHAN F
Format Patent
LanguageEnglish
Slovak
Published 08.11.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are substituted pyrimidines of the general formula (I) wherein R1, R2, R3 and R4 are independently H, alkyl containing 1 to 6 carbon atoms, or perfluoroalkyl containing 1 to 6 carbon atoms; R5 is H or when n is 1 R5 taken together with R3 comprises a double bond, n is 0 to 1, p is 0 to 2, m is 0 to 3; Ar1 and Ar2 are as disclosed in the Description; and are useful for treating hypertension or congestive heart failure and for preventing or treating restenosis following angioplasty; pharmaceutical compositions; and methods for production thereof.
Bibliography:Application Number: SK19920003221