NOVEL ANTICOAGULANT GLYCOSIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF

• Main Authors: KOVACSNE BOZO E, KUSZMANN JANOS, BOROS SANDOR, SZABO GABRIELLA, MORAVCSIK IMRE
• Format: Patent
• Language: English
• Published: 07.05.1999
• Edition: 6

This invention relates to novel 1,5-dithio-pyranosides of formula (I) wherein R1 represents hydrogen, hydroxy or an azido group, R2 represents hydroxy, azido, amino or an acetamido group, R3 represents hydroxy or an azido group, R4 represents hydrogen, methyl or a hydroxymethyl group, R5 represents hydrogen, R4 and R5 together represent a methylene group, R6 represents a nitro, cyano, amidino, aminothiocarbonyl, -C(=NH)-OCH3, -C(=NH)-NH-NH2 or -C(=NH)-SCH3 group, with the proviso that R6 represents only a group other than a nitro or cyano group if R1-R3 each represents hydroxy groups, and R4 as well as R5 represent hydrogen, furthermore that R6 represents only a group other than a nitro group if R1-R3 each represents hydroxy groups, R4 represents a hydroxymethyl group and R5 represents hydrogen, and the acid addition salts thereof formed with organic or inorganic acids, if possible and pharmaceutical compositions containing the same. The compounds of the invention possess valuable therapeutic, particularly anticoagulant properties.