METHOD OF PRODUCTION OF TRANS-6-£2-(SUBSTITUTED-PYROL-1-YL)ALKYL| PYRAN-2-ONE INTERMEDIATES OF THIS METHOD AND PHARMACEUTICAL AGENTS

An improved process for the preparation of trans-6-(2-(substituted-pyrrole-1-yl)alkyl)pyran-2-ones by a novel synthesis is described where (alpha)-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4...

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Bibliographic Details
Main Authors BUTLER DONALD E, NANNINGA THOMAS N, LE TUNG VAN
Format Patent
LanguageEnglish
Published 06.12.1995
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:An improved process for the preparation of trans-6-(2-(substituted-pyrrole-1-yl)alkyl)pyran-2-ones by a novel synthesis is described where (alpha)-metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and specifically, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1H-pyrrole-3-carboxamide, as well as other valuable intermediates used in the processes and prodrugs which are bioconverted to hypolipidemic and hypocholesterolemic agents and pharmaceutical compositions of the same.
Bibliography:Application Number: SK19950001090