5-((PIPERAZIN-1-YL)-3-OXO-PROPYL)-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS

• Main Authors: GOSMINI Romain Luc Marie, ALVEY Luke Jonathan, DE CEUNINCK Frederic Andre, DEPREZ Pierre Marc Marie Joseph, JARY Helene Marie, POP-BOTEZ Iuliana Ecaterina, BREBION Franck Laurent, PEIXOTO Christophe, AMANTINI David, VARIN Marie Laurence Claire
• Format: Patent
• Language: English; Slovenian
• Published: 30.04.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention discloses compounds according to formula I:Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and the compounds of formula I for use in methods of treatment and for use in methods of prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.