1,3- and 1,4-disubstituted piperidines as inhibitors of butyrylcholinesterase for the treatment of Alzheimer's disease and other dementias

Izum se nanaša na nove zaviralce encima butirilholin-esteraza s formulo I in II, v kateri imajo substituente v opisu definiran pomen, v obliki čistih enantiomerov ali zmesi enantiomerov in njihovih farmacevtsko sprejemljivih soli. Izum se nanaša na uporabo teh spojin za zdravljenje Alzheimerjeve bol...

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Bibliographic Details
Main Authors Damijan Knez, Nicolas Coquelle, Jacques-Philippe Colletier, Urban Košak, Boris Brus, Stanislav Gobec
Format Patent
LanguageEnglish
Slovenian
Published 30.09.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Izum se nanaša na nove zaviralce encima butirilholin-esteraza s formulo I in II, v kateri imajo substituente v opisu definiran pomen, v obliki čistih enantiomerov ali zmesi enantiomerov in njihovih farmacevtsko sprejemljivih soli. Izum se nanaša na uporabo teh spojin za zdravljenje Alzheimerjeve bolezni in drugih oblik demenc. This invention relates to new inhibitors of butyrylcholinesterase with general formulas I and II, where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the form of pharmaceutically acceptable salts. The present invention relates to the use of these inhibitors for the treatment of Alzheimer's disease and other forms of dementia.
Bibliography:Application Number: SI20150000076