RESOLUTION OF ( )-METHYL PHENYLS4-S4-SSS4'-(TRIFLUOROMETHYL)-2-BIPHENYLYLCCARBONYLCAMINOCPHENYLC-1-PIPERIDINYLCACETATE

The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphen...

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Bibliographic Details
Main Authors COPMANS ALEX HERMAN, VAN DUN JOANNES PETRUS, HOET JEROME ALBERT JOSEPH, COUCK WOUTER LOUIS J, WILLEMSENS ALBERT LOUIS ANNA
Format Patent
LanguageEnglish
Slovenian
Published 28.06.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
Bibliography:Application Number: SI20100030201T