MONOCLONAL ANTIBODY NEUTRALIZING CATHEPSIN B ACTIVITY AND ITS APPLICATIONS

• Main Authors: KOPITAR-JERALA NATASA, FAN XIAOHUI, PREMZL ALES, BESTAGNO MARCO, BURRONE OSCAR R, TURK VITO, KOS JANKO
• Format: Patent
• Language: English; Slovenian
• Published: 31.12.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a monoclonal antibody capable of neutralizing Cathepsin B. In particular the present invention is concerned with the use of such an antibody for the treatment and detection of diseases associated with an over-expression and/or excessive activity of Cathepsin B such as cancer or arthritis. Predloženi izum se nanaša na monoklonsko protitelo, ki je sposobno nevtralizirati katepsin B. Še zlasti se predloženi izum nanaša na uporabo takšnega protitelesa za zdravljenje ali detekcijo bolezni, povezanih s prekomerno ekspresijo in/ali prekomerno aktivnostjo katepsina B, kot je rak ali artritis.ŕ