AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods...

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Main Authors DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, JOSHI ANAGHA ABHIJIT, BOWLES OWEN JOSEPH, AAY NAING, COSTANZO SIMONA, KENNEDY ABIGAIL R, KOLTUN ELENA, MANALO JEAN-CLAIRE LIMUN, ANAND NEEL KUMAR, BUSSENIUS JOERG, TSANG TSZE H, BLAZEY CHARLES M, CURTIS JEFFRY KIMO, PETO CSABA J, RICE KENNETH D, DUBENKO LARISA
Format Patent
LanguageEnglish
Slovenian
Published 31.08.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
Bibliography:Application Number: SI20060031043T