5-SUBSTITUTED-2-PHENYLAMINO BENZAMIDES AS MEK INHIBITORS

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically accepta...

Full description

Saved in:
Bibliographic Details
Main Authors ISSHIKI YOSHIAKI, IIKURA HITOSHI, MATSUBARA YASUAKI, KOHCHI MASAMI, KOHCHI YASUNORI, MURATA TAKESHI, AIDA SATOSHI, SHIMMA NOBUO, MIZUGUCHI EISAKU, MIWA MASANORI, TSUJII SHINJI, ASO KOSUKE
Format Patent
LanguageEnglish
Slovenian
Published 28.02.2011
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R 1 , R 2 , R 3 , R 4 , and X are the same as defined in the present patent application].
Bibliography:Application Number: SI20050031201T