VACCINE COMPOSITION COMPRISING INTERLEUKIN-15 (IL-15)

Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the imm...

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Main Authors RODRIGUEZ ALFONSO ARMANDO ALEXEI, GERONIMO PEREZ HAYDEE, MORO SORIA ALEJANDRO, PEREA RODRIGUEZ SILVIO ERNESTO, SANTOS SAVIO ALICIA, SILVA RODRIGUEZ RICARDO, MARTINEZ CASTILLO JOSE RAFAEL, MORERA DIAZ YANELIS
Format Patent
LanguageEnglish
Slovenian
Published 30.06.2009
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the immunized host. IL-15 can be presented in this vaccine composition either alone or coupled to a carrier such as the P64k protein with a vaccine adjuvant such as Aluminum hydroxide. Besides, this invention is related to the use of this vaccine for treatment of Rheumatoid arthritis and other IL-15 over-expressing related diseases, and leukemia, where this cytokine acts as a growth factor.
Bibliography:Application Number: SI20030031536T