HEMISYNTHETIC METHOD AND INTERMEDIATES THEREOF

Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from -H,...

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Main Authors CUEVAS CARMEN PHARMA MAR S.A. CALLE DE LA, MANZANARES IGNACIO PHARMA MAR S.A. CALLE DE LA, GALLEGO PILAR PHARMA MAR S.A. CALLE DE LA, FERNANDEZ CAROLINA PHARMA MAR S.A. CALLE DE LA, PEREZ MARTA PHARMA MAR S.A. CALLE DE LA, CHICHARRO JOSE LUIS PHARMA MAR S.A. CALLE DE LA, FRANCESCH ANDRES PHARMA MAR S.A. CALLE DE LA, DE LA CALLE FERNANDO PHARMA MAR S.A. CALLE DE, ZARZUELO MARIA PHARMA MAR S.A. CALLE DE LA
Format Patent
LanguageEnglish
Slovenian
Published 30.06.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from -H, -OH or -OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both -H ozone is -H and the other is -OH, -OCH3 or -OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from -H or -OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.
Bibliography:Application Number: SI20000030599T