Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor

The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-pro panol: The present invention is further directed to a process for the preparation of a (2S)-(+)-c...

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Bibliographic Details
Main Authors SINAY TERRY GENE JR, WALINSKY STANLEY WALTER, RAINVILLE JOSEPH PHILIP
Format Patent
LanguageEnglish
Slovenian
Published 28.02.2005
Edition7
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-pro panol: The present invention is further directed to a process for the preparation of a (2S)-(+)-compound of formula (II): wherein R is a protecting group. In addition, the present invention relates to intermediates useful in said processes.
Bibliography:Application Number: SI20010030185T