Substituted Imidazolidin-2,4-dione derivatives as immunomodulators

5,5-Disubstd. 3-heteroaryl-imidazolidine-2,4-dione cpds. of formula (I) are new: R = 1-6C alkyl or 3-6C cycloalkyl; R = 1-6C alkyl, Ph, -(CH2)1-3-Ph or -(CH2)1-4-COOR ; or R + R = -(CH2)4-6-, -(CH2)2O(CH2)2- or -CH2-o-C6H4-CH2-; R = H, 1-5C alkyl or -(CH2)1-4-COOR ; R = pyridinyl (opt. mono- or disu...

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Main Authors WNENDT STEPHAN DR, ZIMMER OSWALD DR, BOEHLKE HORST DR, ZWINGENBERGER KAI DR, GEIST-RUDOLF CORNELIA DR
Format Patent
LanguageEnglish
Slovenian
Published 31.10.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:5,5-Disubstd. 3-heteroaryl-imidazolidine-2,4-dione cpds. of formula (I) are new: R = 1-6C alkyl or 3-6C cycloalkyl; R = 1-6C alkyl, Ph, -(CH2)1-3-Ph or -(CH2)1-4-COOR ; or R + R = -(CH2)4-6-, -(CH2)2O(CH2)2- or -CH2-o-C6H4-CH2-; R = H, 1-5C alkyl or -(CH2)1-4-COOR ; R = pyridinyl (opt. mono- or disubstd. by Me), pyrazinyl, R -substd. thiazolyl, methyl-substd. isoxazolyl, benzo-2,1,3-thiadiazolyl or 5-(R )-1,3,4-thiadizol-2-yl; R = 1-3C alkyl; R = H, 1-4C alkyl, Ph or benzyl; R = H, 1-4C alkyl or CF3.
Bibliography:Application Number: SI19960030066T