EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS

EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGSThe application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemi...

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Main Authors SUDHAKAR, ANANTHA, SABESAN, VIJAY, NGUYEN, HOA, N, WU, GEORGE, G, THIRUVENGADAM, TIRUVETTIPURAM, K, CUI, JIAN, WANG, TAO, HUANG, MINGSHENG, ZAVIALOV, ILIA, YANG, XIAOJING, XIE, JI, LIM, NGIAP KIE, CHEN, FRANK, XING, LIAO, JING, POIRIER, MARC, KWOK, DAW-LONG
Format Patent
LanguageEnglish
Published 30.08.2013
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Summary:EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGSThe application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following. (I)
Bibliography:Application Number: SG20130053558