DUAL-ACTING PHARMACEUTICAL COMPOSITIONS BASED ON SUPERSTRUCTURES OF ANGIOTENSIN RECEPTOR ANTAGONIST/BLOCKER (ARB) AND NEUTRAL ENDOPEPTIDASE (NEP) INHIBITOR

DUAL-ACTING PHARMACEUTICAL COMPOSITIONS BASED ON SUPERSTRUCTURES OF ANGIOTENSIN RECEPTOR ANTAGONIST/BLOCKER (ARB) AND NEUTRAL ENDOPEPTIDASE (NEP) INHIBITORSolid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct comp...

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Main Authors AL-FAYOUMI, SULIMAN, KUMARAPERUMAL, NATRAJAN, ZANNOU, ERIKA, AINA, HU, JIAHUI, ROYCE, ALAN, EDWARD, RUEGGER, COLLEEN
Format Patent
LanguageEnglish
Published 28.12.2012
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Summary:DUAL-ACTING PHARMACEUTICAL COMPOSITIONS BASED ON SUPERSTRUCTURES OF ANGIOTENSIN RECEPTOR ANTAGONIST/BLOCKER (ARB) AND NEUTRAL ENDOPEPTIDASE (NEP) INHIBITORSolid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct compression process or a compaction process such as roller compaction. Such solid oral dosage forms feature an immediate release profile that allows for fast release of the therapeutic agent. A particularly useful supramolecular complex is trisodium [3-((1S,3R)-1-bipheny1-4-ylmethy1-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3'-methy1-2'-(pentanoy1{21-(tetrazol-5-ylate)biphenyl-4'- yl methyl}am i no)butyrate]hem i penta hyd rate.Figure 1
Bibliography:Application Number: SG20120081394