NEW NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

2-Fluoro-N-[3-hydroxy-2-(7-methoxy-naphthalen-1-yl)-propyl]-acetamide (I), its enantiomers and base addition salts, are new. 2-Fluoro-N-[3-hydroxy-2-(7-methoxy-naphthalen-1-yl)-propyl]-acetamide of formula (I), its enantiomers and base addition salts, are new. An independent claim is included for th...

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Main Authors CAIGNARD DANIEL-HENRI, PERES BASILE, SPEDDING MICHAEL, MILLAN MARK, BERTHELOT PASCAL, SABAOUNI AHMED, DELAGRANGE PHILIPPE, YOUS SAID
Format Patent
LanguageEnglish
Published 28.01.2008
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Summary:2-Fluoro-N-[3-hydroxy-2-(7-methoxy-naphthalen-1-yl)-propyl]-acetamide (I), its enantiomers and base addition salts, are new. 2-Fluoro-N-[3-hydroxy-2-(7-methoxy-naphthalen-1-yl)-propyl]-acetamide of formula (I), its enantiomers and base addition salts, are new. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen; Gastrointestinal-Gen; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Cerebroprotective; Contraceptive; Endocrine-Gen; Immunomodulator; Cytostatic. MECHANISM OF ACTION : Melatonin receptor binder. The ability of (I) to bind with melatonin was tested. The results showed that 2-fluoro-N-[3-hydroxy-2-(7-methoxy-1-naphthyl)propyl]acetamide exhibited an inhibition constant value of 7.7 nM and 0.5 nM to bind with melatonin receptors MT 1and MT 2, respectively.
Bibliography:Application Number: SG20070047889