HETEROARYL DERIVATIVE, METHOD FOR PRODUCING THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT

The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor rece...

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Main Authors SEOK, Ji Yoon, KO, Yi Kyung, CHOI, Hwan Geun, KIM, Da Eun, KIM, Seung Su, SON, Jung Beom, KANG, Se In, HWANG, Dong Keun, KANG, Ju Hee, KIM, Nam Doo, RYU, Min Seok, HAN, Ah Reum, KO, Eun Hwa, KIM, Hwan, LEE, Youn Ho, LEE, Sun Hwa
Format Patent
LanguageEnglish
Published 28.10.2021
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Summary:The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and can thus be usefully used in the treatment of lung cancer.
Bibliography:Application Number: SG11202110376X