NON-HUMAN ANIMALS COMPRISING A HUMANIZED COAGULATION FACTOR 12 LOCUS

Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized coagulation factor XII (F12) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals com...

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Main Authors MACDONALD, Lynn, CHALOTHORN, Dan, MITNAUL, Lyndon, MORTON, Lori, ZAMOLODCHIKOV, Daria, TANG, Yajun, ALESSANDRI-HABER, Nicole
Format Patent
LanguageEnglish
Published 29.09.2021
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
NEW BREEDS OF ANIMALS
ORGANIC CHEMISTRY
PEPTIDES
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
TRAPPING
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Summary:Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized coagulation factor XII (F12) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized F12 locus express a human coagulation factor XII protein or a chimeric coagulation factor XII protein, fragments of which are from human coagulation factor XII. Methods are provided for using such non-human animals comprising a humanized F12 locus to assess in vivo efficacy of human-coagulation-factor-XII-targeting reagents such as nuclease agents designed to target human F12. A short isoform of F12 that is produced locally in the brain, and methods of using the short isoform, are also provide.
Bibliography:Application Number: SG11202108454R