METHODS OF MANUFACTURING OF NIRAPARIB

• Main Authors: STEWART, Alistair, TOTO, Anthony Joseph, WU, George, CHEN, Frank Xing
• Format: Patent
• Language: English
• Published: 28.11.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT ill~~~ 011101010VIIIOH olo oloionsu turnoff oimIE (10) International Publication Number WO 2018/200517 Al (51) International Patent Classification: C07D 211/18 (2006.01) C07D 401/10 (2006.01) (21) International Application Number: PCT/US2018/029131 (22) International Filing Date: Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) W O 20 18/ 2005 17 Al 24 April 2018 (24.04.2018) Published: (25) Filing Language: English - with international search report (Art. 21(3)) (26) Publication Language: English (30) Priority Data: 62/489,387 24 April 2017 (24.04.2017) US 62/489,415 24 April 2017 (24.04.2017) US (71) Applicant: TESARO, INC. [US/US]; 1000 Winter St. North #3300, Waltham, Massachusetts 02451 (US). (72) Inventors: STEWART, Alistair; c/o Tesaro, Inc., 1000 Winter St. North #3300, Waltham, Massachusetts 02451 (US). TOTO, Anthony Joseph; 872 Boonton Avenue, Boonton, New Jersey 07005 (US). CHEN, Frank Xing; 12 Bradford Lane, Plainsboro, New Jersey 08536 (US). WU, George; c/o Tesaro, Inc., 1000 Winter St. North #3300, Waltham, Massachusetts 02451 (US). (74) Agent: ESPINO, Christine, G.; Proskauer Rose LLP, One International Place, Boston, Massachusetts 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: METHODS OF MANUFACTURING OF NIRAPARIB (57) : Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib.