INHIBITORS AND ANTAGONISTS OF GPR84 FOR THE TREATMENT OF ENDOMETRIOSIS

• Main Authors: OPPERMANN, Udo, MARTINEZ, ESTRADA, OBENDORF, Maik, LANGER, Gernot, SHANG, Catherine, SACHER, Frank
• Format: Patent
• Language: English
• Published: 28.11.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 November 2018 (22.11.2018) WIPO I PCT olimion ono oIIIOHDIDIIl 11°1°111°1111mo Hs (10) International Publication Number WO 2018/210822 Al (51) International Patent Classification: A61K 31/00 (2006.01) A61P 29/00 (2006.01) A61K 31/20 (2006.01) Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) (21) International Application Number: (22) International Filing Date: PCT/EP2018/062544 Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 15 May 2018 (15.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17171351.4 16 May 2017 (16.05.2017) EP (71) Applicant: BAYER PHARMA AKTIENGESEL- LSCHAFT [DE/DE]; Miillerstr. 178, 13353 Berlin (DE). (72) Inventors: SACHER, Frank; Erich-Weinert-Str. 134, 10409 Berlin (DE). OBENDORF, Maik; Am Horn 13e, 99425 Weimar (DE). LANGER, Gernot; Mainstr. 32, 14612 Falkensee (DE). MARTINEZ, ESTRADA, Fer- nando; 62 Church Road, GU8 5JD Milford, Godalming (GB). OPPERMANN, Udo; Foxcombe Road, Peggy's Cot- tage, OX1 5DQ, Oxford (GB). SHANG, Catherine; 4/10 Bruce St, Toorak, Melbourne, 3142 (AU). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein NRW (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). cc O (54) Title: INHIBITORS AND ANTAGONISTS OF GPR84 FOR THE TREATMENT OF ENDOMETRIOSIS 00 (57) : The present invention relates to an antagonist or inhibitor of G protein-coupled receptor 84 (GPR84) for use in the O treatment and/or prevention of a patient suffering from, at risk of developing, and/or being diagnosed for endometriosis, as well as methods of screening for such antagonist or inhibitor as well as methods for diagnosis. O