PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

• Main Authors: KISS, Gert, GILL, Adrian, AAY, Naing, MELLEM, Kevin, SEMKO, Christopher, BUCKL, Andreas, KOLTUN, Elena S
• Format: Patent
• Language: English
• Published: 27.08.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) REVISED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIPO I PCT 1111111111111011101010111101111010 III 00111111111110 IM EMO 1110# (10) International Publication Number WO 2018/136264 A9 (51) International Patent Classification: C07D 401/04 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) A61K 31/438 (2006.01) (21) International Application Number: PCT/US2018/013018 (22) International Filing Date: 09 January 2018 (09.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/449,529 23 January 2017 (23.01.2017) US (71) Applicant: REVOLUTION MEDICINES, INC. [US/US]; 700 Saginaw Drive, Redwood City, California 94063 (US). (72) Inventors: GILL, Adrian; c/o Revolution Medicines, Inc., 700 Saginaw Drive, Redwood City, California 94063 (US). AAY, Naing; c/o Revolution Medicines, Inc., 700 Saginaw Drive, Redwood City, California 94063 (US). MELLEM, Kevin; c/o Revolution Medicines, Inc., 700 Saginaw Drive, Redwood City, California 94063 (US). BUCKL, Andreas; c/o Revolution Medicines, Inc., 700 Saginaw Drive, Red- wood City, California 94063 (US). KOLTUN, Elena S.; c/ o Revolution Medicines, Inc., 700 Saginaw Drive, Redwood City, California 94063 (US). SEMKO, Christopher; c/o Revolution Medicines, Inc., 700 Saginaw Drive, Redwood City, California 94063 (US). KISS, Gert; c/o Revolution Medicines, Inc., 700 Saginaw Drive, Redwood City, Cali- fornia 94063 (US). (74) Agent: TONG, Connie C. et al.; Cooley LLP, 1299 Penn- sylvania Avenue, NW, Suite 700, Washington, District of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: - with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the revised international search report: 25 October 2018 (25.10.2018) (15) Information about Correction: see Notice of 25 October 2018 (25.10.2018) 00 (54) Title: PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS O (57) : The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are C pharmaceutical compositions comprising the same.