BIOMATRIX SCAFFOLDS FOR USE IN DIAGNOSING AND MODELING CANCER

Described herein are in vitro cancer metastasis models that recapitulate biological facets of organ specificity as indicated by the behavior of human colorectal cancer cells when on substrata of liver and lung biomatrix scaffolds, organ-specific matrix extracts generated by novel decellularization s...

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Bibliographic Details
Main Authors TIAN, Xi, WANG, Andrew Zhuang, REID, Lola M
Format Patent
LanguageEnglish
Published 27.02.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:Described herein are in vitro cancer metastasis models that recapitulate biological facets of organ specificity as indicated by the behavior of human colorectal cancer cells when on substrata of liver and lung biomatrix scaffolds, organ-specific matrix extracts generated by novel decellularization strategies. Tumor cells spontaneously formed colonies that mimicked in vivo metastatic lesions in terms of histology, biology and genetic and other phenotypic traits. Not to be bound by theory, it is postulated that responses of tumors to radiation or chemotherapeutic agents proved dependent on the matrix substratum used; thus, thus the scaffolds are believed to provide a powerful tool for cancer research and diagnosis.
Bibliography:Application Number: SG20191100057W