FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES

A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nocice...

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Main Authors FORICHER, YANN, DELIGNY, MICHAEL, MAC COSS, MALCOLM, DE HARO GARCIA, TERESA, HEER, JAG PAUL, XUAN, MENGYANG, CALMIANO, MARK DANIEL, SELBY, MATTHEW DUNCAN, JOHNSON, JAMES ANDREW, QUINCEY, JOANNA RACHEL, SWINNEN, DOMINIQUE LOUIS LÉON, SHAW, MICHAEL ALAN, ZHU, ZHAONING, FILOCHE-ROMME, BRUNO, SCHIO, LAURENT, BROOKINGS, DANIEL CHRISTOPHER, JADOT, SOPHIE, EVRARD, YVES, HUTCHINGS, MARTIN CLIVE, KEYAERTS, JEAN
Format Patent
LanguageEnglish
Published 27.04.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.
Bibliography:Application Number: SG20171101796X