CAROTENOID DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICALLY ACCEPTABLE ESTER OR AMIDE THEREOF

• Main Authors: TAKAHASHI, JIRO, FUJITA, TAKASHI, NISHIDA, YASUHIRO, KOBAYASHI, SATOSHI, SHINOHARA, RYOMA
• Format: Patent
• Language: English
• Published: 29.12.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The object of the present invention is to find a carotenoid compound that is excellent in water solubility. A carotenoid derivative having a formula (I): wherein X represents a carbonyl group or a methylene group, one of R 1 and R 2 represents (a) or (b) and the other represents (a), (b), (c) or a hydrogen atom: (a): -CO-A-B-D wherein A represents an alkylene group an alkenylene group, etc., B represents a formula of -S(O) n - or a formula of -NR 4 CONR 5 - and D represents a hydrogen atom, a carboxy group, etc., (b): -CO-E-F wherein E represents an alkylene group or a formula of -NR 3 - wherein R 3 represents (a1) a hydrogen atom, (b1) an alkyl group etc., and F represents a sulfo group and (c): -CO-G wherein G represents a hydrogen atom, an alkyl group, 1 etc., a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester or amide thereof.