GROUP B STREPTOCOCCUS POLYSACCHARIDE-PROTEIN CONJUGATES, METHODS FOR PRODUCING CONJUGATES, IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATES, AND USES THEREOF

• Main Authors: ANDERSON, Annaliesa Sybil, KIM, Jin-Hwan, YANG, Cindy Xudong, SINGH, Suddham, SCULLY, Ingrid Lea, DONALD, Robert G.K, BHUPENDER BHALLA, Amardeep Singh, KHANDKE, Lakshmi, JANSEN, Kathrin Ute, KAINTHAN, Rajesh Kumar, LIBERATOR, Paul, PRASAD, Avvari Krishna, RUPPEN, Mark Edward, GU, Jianxin
• Format: Patent
• Language: English
• Published: 30.03.2021

The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.